Kakeru is the groups' leader to lead other survivors to safety. He is the tactician, serious and has a marks of leadership and often clashes with Ritsu. He also had a dog named Shiho, who assist him during their fight with zombies. He has a soft spot for Yuna and Clint. He also has good relationship with Paolo, his father figure. Kakeru's choice of weapon is his sniper rifle, dual magnum pistol and his silver metalic skeletal structure which enables him to retracted his nails to bashes off the infected with a single swipe due to the experimentation of his immunity systems and his retractable genetic systems collided and became a successful experiment before the breach of the infection outbreak spreaded.
Yuna Nakashima:
Kakeru's fiancee. He met her when the bullies tried to bully her and Kakeru steps in and beat them up. They met again as she wants to thank him though he shyly talks to her. Two days after infection, Yuna and Rika went to find Kakeru to propose him, though he calmly listening Rika's death threats, he said yes. During Zombie apocalypse breaks out, Kakeru shoots the infected behind them while calling out reinforcement to take them to safety by sending helicopter. Only Yuna remained along with their teacher, Baro Takashima, Kakeru's guardian, to fight off the zombies with the equipment to Yuna, as she's good with gun but Baro was bitten as Kakeru shoots the zombie. As a final request, Baro told a tearful Kakeru to kill him. He refuses, only to have Yuna rationalize him to put him to rest rather than watch him misery. With a emotional farewell to his beloved teacher that always care for him for a son, he pulls the trigger, killing him instantly leaving Kakeru cried in despair. As Kakeru must find other survivors, Yuna joins him despite he doesn't want to lose her, she said she will stay by his side so he wont be alone and confesses her feelings, which he in return kisses her. Kakeru is very protective of her and when he learned that Soichi cruelly force her to repeat classes for a day, he is very angry and upset and the same time, hold a grudge on him. They love each other and both became emotional sad and grief if either two were killed and refuses to left behind when incapacitated or locked inside. She never cared about his genetic mutation, she loved him as he was as she too, like him before, experimented to fight the infection and like Kakeru, she survived the experiment that enables her to turn her body into crystalized form.
Clint Scofield:
Kakeru's relationship with Clint is much like brother figure, like Namco's Guntz the Wolf and Klonoa the Cat, and surrogate father. Kakeru looks after Clint after his parents were killed by the horde of Zombies as their supposed summer vacation was sieged as they hid him in the closet and his mother told him never go outside no matter what happens. Kakeru softly informed that his parents weren't be with him anymore, which Clint sadly accepts their death, understanding their noble love and sacriffice for him to be safe. Not wanting to be left alone, Kakeru took him in. When Ritsu made fun of him and patronizing him for a kid, Kakeru boldly told him to knock it off as Clint snapped at him to leave him alone. Kakeru is very protective of him since he's still a kid and if he was killed, Kakeru began to cry and said "I left you alone again" sobbing. Same goes to Clint as he said when Kakeru died saying "Kakeru..not you too..". When Clint was incapacitated, Kakeru helped him up saying "It's okay, I got'cha...". He also told him to run when he accidentaly startled the Witch. Clint enjoyed teasing Kakeru about girls and Kakeru, feel annoyed and embarassed, told him to stop. He even allows him to play with Shiho as he likes Dogs and when Clint was chased by Witch, Shiho immediately followed her behind and grabbed her leg, making the Witch loose balance and mauled her to death or cr0wned by an angry Kakeru.
Ritsu Miyamoto:
Kakeru and Ritsu dislike to each other, like Bill to Francis and Coach to Nick. Only differences is they are high school students, Ritsu is delinquent student senior in 3-D and Kakeru is honorable student junior 2-B,Ritsu dislike teachers while Kakeru respects them (except one, Soichi Miura, which the both of them had in common). Ritsu hates dogs as he was a kid being chased by them and Kakeru shown his displeasure expression when he refuses to let Shiho in which he tells him that he needed him for a look out, much to his dismay. After a few month, he started to accept Shiho after she saved him from Hunter by rammed it and mauled it to death. When Ritsu insulted Clint and patronizing him to let the adults do the work, Kakeru boldly told him to leave Clint alone or smack him on the head. When meeting the L4D 1 characters, Ritsu shown disdain towards them about lowering the bridge and showing his rude remarks towards them unaware that they lost Bill, which resulted Kakeru became furiously offended and reprimanding him about their struggle to survive for the sake of Bill by saying with pulling him by the ear or point his gun at him to watch his mouth and said that "they've been through this s### and they lost a good man here, show some respect!!". Still, they look after each other and show some respect if either of them killed.
Paulo son Carpio:
Kakeru looked up for him as a father figure after the death of his teacher and guardian, Baro Takashima. They closed one another like Zoey and Bill relationship. Kakeru affectionately calls him "pops" and Paulo calls him "Kid" in more friendly way. Paulo seems to understand Kakeru's pain and loss for his good friend, teacher and guardian, Baro and promised to Kakeru's father, Kazuya, to protect his son. Since Paolo is also an army and good with grenade, Kakeru voluteers him to join in. Paolo worries about Kakeru and Ritsu bickering and when things get out of hand, he stops them immediately, acting as a mediator for the two. The two of them often closed one another and they also shown grief if two of them killed.
Shiki Miyamoto:
His upper classmate from 4-A and best friend, both captivity and school. Shiki is the older sister of Ritsu and only family after their divorced parents were killed by the infected. The older sister of the group, she, like Kakeru, aloof, calm and blunt and also the polite ones and doesn't swear like Kakeru and Ritsu. She and Kakeru often look after one another.
Shiho the Wolf Malamute dog:
Kakeru found her as a puppy and the only sole survivor after her mother and siblings died due to the infection spreaded. Shiho is very loyal to Kakeru and very friendly towards the group, including Clint, Yuna, Paolo, Ritsu and Shiki. If a player chose Kakeru, Shiho acts as a watch dog for a lookout. Like Kakeru, she is aware the surroundings and will attack them during the crescendo event. Shiho was on guard when she saw the Witch and started to growl when she sensed the Witch became disturbed if the player startled the Witch and incapacitated, Shiho immediately jumps at her, biting her down
and cr0wned, earned a nicknamed "Witch Hunting Dog". Shiho also shown sorrow by howls at the dead player if played as Kakeru. She's became important role when she faces special infected and helping the incapacitated by teviving them with a lick and grabbed the nearly falling survivor when they were holding on the ledges by grabbing at the collar.
